This guideline provides a set of recommendations and aspects to be considered for the assessment of applicability in the context of a relative effectiveness assessment.
Applicability, also known as external validity/ generalisability/ or transposability, is the extent to which the effects observed in clinical studies are likely to reflect the expected results when a specific intervention is applied to the population of interest. In case of a relative effectiveness assessment (REA), the population of interest refers to the patient population that is being assessed as part of the REA. Internal validity is the extent to which the design, conduct, analysis and reporting of a randomised controlled trial (RCT) eliminate the possibility of bias. Bias is defined as the systematic distortion of the estimated intervention effect away from the “truth”. ‘Internal validity’ is discussed in more detail in the EUnetHTA guideline on internal validity.
Please find the guideline on applicability at the bottom of this page
This document is part of the JA1 Final Technical Report as Deliverable
NOTE: For the full Technical Report, please follow this link.